GLP-1 Medications and PCOS: Why Nutrition Still Matters During and After Medication

If you’ve been prescribed a GLP-1 medication like Ozempic, Saxenda, or Mounjaro for PCOS-related weight gain, you're in the right place to learn more about it from a nutritional perspective.

These drugs can lead to short-term weight loss, and for many women with PCOS who’ve struggled for years, they can feel like a lifeline.

But there’s something many aren’t told: without the right nutrition and hormone support, the long-term results often don’t last. I’ve worked with women who feel frustrated and confused when the weight creeps back, or symptoms return, after stopping the medication.

That’s where the right nutrition, support and sustainable strategy makes all the difference.

What GLP-1s Actually Do

GLP-1 receptor agonists mimic a gut hormone that affects appetite, insulin response and gastric emptying. They often lead to reduced hunger and slower digestion, which can help with weight loss.

But they don’t address the root causes of PCOS, including:

• Insulin resistance

• Inflammation

• Hormone imbalances

• Poor metabolic flexibility

• Poor gut health

And they don’t provide the nutrients, protein, fibre or movement strategies your body needs to preserve metabolism, hormones and long-term results.

Why Women with PCOS Need More Than Medication

1. GLP-1s can reduce appetite, but also reduce protein intake

Many women feel full quickly and unintentionally under eat protein, which is essential for:

• Muscle maintenance

• Blood sugar control

• Supporting metabolism and hormone pathways

This can lead to muscle loss, fatigue, and even worsening insulin sensitivity over time—especially when coming off the medication.

2. You’re not absorbing the same nutrients

Because GLP-1s slow digestion, some women experience bloating, nausea or nutrient absorption issues. That matters when you’re already more prone to nutrient depletions with PCOS, such as magnesium, B12, zinc and omega-3s.

3. They don’t fix insulin resistance

GLP-1s help with blood sugar regulation, but unless you’re also making food and lifestyle changes, the root drivers of PCOS persist. This is often why weight returns or symptoms flare when you stop the drug.

4. You need a plan for after the meds

Without support, coming off GLP-1s can lead to:

• Rebound hunger

• Blood sugar crashes

• Rapid weight regain

• Low mood and energy

The Role of Food-First, Hormone-Focused Support

Whether you’re currently using a GLP-1 or planning to stop, nutrition still plays a central role in:

• Preserving muscle mass and metabolism

• Rebalancing hormones like insulin, oestrogen and androgens

• Preventing blood sugar crashes and energy dips

• Improving gut health, digestion and inflammation

• Creating sustainable, real-life habits you can stick with

What I Focus On Inside the Hormone Shift Method

In my 12-week programme, I work with women with PCOS to support their hormones, metabolism and long-term health, whether they’re on medication or not.

Here's how:

• Protein-first meals that protect muscle and curb cravings

• Realistic blood sugar balance strategies (no carb cutting or extremes)

• Functional testing (e.g. DUTCH, nutrients, microbiome) when needed

• Phase-specific hormone support (e.g. ovulation, inflammation, oestrogen clearance)

• Weekly guidance and coaching so you're not doing it alone

You won’t be guessing what to eat. And you won’t be relying on willpower alone!

You Don’t Have to Choose Between Medication or Nutrition

GLP-1s can be one tool, but they’re not a solution on their own. Whether you stay on them, taper off, or avoid them entirely, supporting your body’s underlying needs is still essential. Here's a link to the NHS recommendations and information about weight loss injections.

If you’re looking for a practical, evidence-based approach that supports your hormones, not just the number on the scale, I’d love to help.

Ready to personalise your plan?

Hi I'm Lisa, BANT registered nutritionist and health coach, helping women who want to balance their hormones and lose weight. My programme is suitable for women with PCOS.

I create personalised online nutrition plans for hormone health and weight loss, which can provide a more effective and sustainable approach to achieving your health goals. I work online with clients locally in Manchester, across the UK and Europe.

Investing in a tailored online nutrition plan, such as my PCOS hormone balance and weight loss nutrition programme. not only helps in balancing hormones and improving fertility, but also paves the way for successful, long-term weight management.

Book your FREE 30-minute online consultation to discover how personalised nutrition can help you thrive.

Updated in June 2025 to reflect new PCOS research and nutrition strategies. 

DISCLAIMER: The content on this webpage is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your doctor or qualified healthcare provider. Never disregard professional medical advice or delay in seeking it because of something you have read on this website.